Ospedale Molinette di Torino, scoperto meccanismo molecolare che provoca la crescita delle metastasi nel cervello, dalla Neuro-oncologia.

12 luglio 2018
/
Views 88

Scoperto meccanismo molecolare che provoca la crescita delle metastasi nel cervello provenienti da tumori del polmone e della mammella.

Lo studio, effettuato dalla Neuro-oncologia dell'ospedale Molinette di Torino e dai ricercatori del CNR (CNIO) di Madrid, è stato appena pubblicato sulla prestigiosa rivista internazionale Nature Medicine.

Le metastasi cerebrali rappresentano una complicanza sempre più frequente di tumori solidi, quali quelli del polmone e della mammella. Purtroppo nel caso delle metastasi al cervello, al di là della chirurgia e della radioterapia, la terapia farmacologica è tuttora limitata ed insoddisfacente.

Il Gruppo di ricerca Neuro-Oncologico del Dipartimento di Neuroscienze dell'ospedale Molinette della Città della Salute di Torino, diretto dal professor Riccardo Soffietti, da anni riconosciuto a livello nazionale ed internazionale quale Centro di eccellenza per le Neoplasie cerebrali, in collaborazione con ricercatori di base del CNR (CNIO) di Madrid, ha individuato un nuovo meccanismo molecolare critico per la crescita nel cervello di metastasi provenienti da tumori del polmone e della mammella e che potrà rappresentare in futuro un bersaglio terapeutico. La ricerca è stata recentemente pubblicata sulla prestigiosa rivista internazionale Nature Medicine.

Il contributo innovativo del Gruppo Neuro-Oncologico torinese (Riccardo Soffietti, Roberta Rudà, Federica Franchino e Alessia Pellerino), in stretta collaborazione con l'anatomopatologo dottor Luca Bertero (Divisione di Anatomia Patologica dell'ospedale Molinette), è consistito nel dimostrare che la crescita delle cellule tumorali metastatiche nel cervello è facilitata dalla presenza di un fattore molecolare (STAT3), non tanto sulle cellule tumorali stesse, ma su cellule del cervello sano (i cosiddetti astrociti reattivi), che viceversa erano sempre state considerate una barriera difensiva. Per arrivare a questo risultato sono stati studiati circa 100 campioni di metastasi cerebrali provenienti da interventi neurochirurgici e si è visto che i pazienti con espressione di STAT3 sugli astrociti reattivi hanno una sopravvivenza molto più breve. La prossima tappa sarà quella di verificare in studi clinici la possibilità di bloccare con farmaci specifici la STAT3.

Suggeriti dalla redazione

L’elefante bianco e la tigre verde, quando il manuale d’impresa parla la lingua della realtà

Redazione

Conto Termico 3.0: incentivi diretti e risparmio immediato su impianti e consumi energetici

Redazione

Milano è la meta preferita da britannici e portoghesi per iniziare il 2026, secondo Jetcost

Redazione

Bilocali a Milano: la mappa e la classifica dei prezzi nelle varie zone della città

Redazione

Nuova tegola per Roberto Saviano, condannato per diffamazione in Gomorra

Redazione

Google assistant meglio di Siri, Alexa e Cortana

Redazione

Tags: citta della salute molinette salute salute tumori

FreeMarker template error (HTML_DEBUG mode; use RETHROW in production!)

mp_in_home_contents query does not work.
Using Parameters:{CATEGORY_ID=31574, cache=freemarker.template.FalseTemplateBooleanModel@36347a9e, HEADING_ID=2313, max=10, SUB_CATEGORY_ID=31887, var=last_contents, name=mp_in_home_contents, start=0}
Given Message:Communications link failure
The last packet successfully received from the server was 91.417 milliseconds ago. The last packet sent successfully to the server was 91.417 milliseconds ago.
----
FTL stack trace ("~" means nesting-related):
- Failed at: @query name=name cache=false start=st... [in template "dev.sevendaysweb.com/layouts/macro/content_suggested.ftl" in macro "suggested_contents" at line 221, column 9]
- Reached through: @suggested_contents name=(mpName + "i... [in template "dev.sevendaysweb.com/layouts/macro/content_suggested.ftl" in macro "content_suggested" at line 81, column 41]
- Reached through: @query name="categories_area_sect" ca... [in template "dev.sevendaysweb.com/layouts/macro/content_suggested.ftl" in macro "content_suggested" at line 8, column 9]
- Reached through: @content_suggested bundle.OCDetail, "... [in template "dev.sevendaysweb.com/layouts/macro/content_details.ftl" in macro "content_details" at line 358, column 25]
- Reached through: @content var="c" show_last_content=ca... [in template "dev.sevendaysweb.com/layouts/macro/content_details.ftl" in macro "content_details" at line 118, column 9]
- Reached through: @content_details img_full_width=img_f... [in template "dev.sevendaysweb.com/layouts/default.ftl" in macro "contents_column" at line 9, column 13]
- Reached through: @contents_column [in template "dev.sevendaysweb.com/layouts/macro/skeleton.ftl" in macro "container" at line 412, column 49]
- Reached through: @query name="count_areas" cache=false... [in template "dev.sevendaysweb.com/layouts/macro/skeleton.ftl" in macro "container" at line 254, column 5]
- Reached through: @container context, "[left-mid-", "[c... [in template "dev.sevendaysweb.com/layouts/macro/skeleton.ftl" in macro "html" at line 111, column 33]
- Reached through: @cache sv=search_val [in template "dev.sevendaysweb.com/layouts/macro/skeleton.ftl" in macro "html" at line 66, column 9]
- Reached through: @html cat_layout="home" cat_title=tru... [in template "dev.sevendaysweb.com/layouts/default.ftl" at line 24, column 1]
----
Java stack trace (for programmers):
----
freemarker.template.TemplateException: [... Exception message was already printed; see it above ...]
at it.treis.utils.freemarker.CategoryCachedQueryResultDirective.execute(CategoryCachedQueryResultDirective.java:217)
at freemarker.core.Environment.visit(Environment.java:445)
at freemarker.core.UnifiedCall.accept(UnifiedCall.java:101)
at freemarker.core.Environment.visit(Environment.java:366)
at freemarker.core.Environment.invoke(Environment.java:775)
at freemarker.core.UnifiedCall.accept(UnifiedCall.java:83)
at freemarker.core.Environment.visit(Environment.java:330)
at freemarker.core.Environment.visit(Environment.java:372)
at freemarker.core.IteratorBlock$IterationContext.executedNestedContentForCollOrSeqListing(IteratorBlock.java:291)
at freemarker.core.IteratorBlock$IterationContext.executeNestedContent(IteratorBlock.java:271)
at freemarker.core.IteratorBlock$IterationContext.accept(IteratorBlock.java:242)
at freemarker.core.Environment.visitIteratorBlock(Environment.java:642)
at freemarker.core.IteratorBlock.acceptWithResult(IteratorBlock.java:107)
at freemarker.core.IteratorBlock.accept(IteratorBlock.java:93)
at freemarker.core.Environment.visit(Environment.java:330)
at freemarker.core.Environment.visit(Environment.java:372)
at freemarker.core.Environment$NestedElementTemplateDirectiveBody.render(Environment.java:2900)
at it.treis.utils.freemarker.CategoryCachedQueryResultDirective.execute(CategoryCachedQueryResultDirective.java:202)
at freemarker.core.Environment.visit(Environment.java:445)
at freemarker.core.UnifiedCall.accept(UnifiedCall.java:101)
at freemarker.core.Environment.visit(Environment.java:366)
at freemarker.core.Environment.invoke(Environment.java:775)
at freemarker.core.UnifiedCall.accept(UnifiedCall.java:83)
at freemarker.core.Environment.visit(Environment.java:330)
at freemarker.core.Environment.visit(Environment.java:372)
at freemarker.core.Environment$NestedElementTemplateDirectiveBody.render(Environment.java:2900)
at it.treis.utils.freemarker.ContentCachedResultDirective.render(ContentCachedResultDirective.java:201)
at it.treis.utils.freemarker.ContentCachedResultDirective.execute(ContentCachedResultDirective.java:181)
at freemarker.core.Environment.visit(Environment.java:445)
at freemarker.core.UnifiedCall.accept(UnifiedCall.java:101)
at freemarker.core.Environment.visit(Environment.java:366)
at freemarker.core.Environment.invoke(Environment.java:775)
at freemarker.core.UnifiedCall.accept(UnifiedCall.java:83)
at freemarker.core.Environment.visit(Environment.java:330)
at freemarker.core.Environment.visit(Environment.java:372)
at freemarker.core.Environment.invoke(Environment.java:775)
at freemarker.core.UnifiedCall.accept(UnifiedCall.java:83)
at freemarker.core.Environment.visit(Environment.java:330)
at freemarker.core.Environment.visit(Environment.java:372)
at freemarker.core.Environment$NestedElementTemplateDirectiveBody.render(Environment.java:2900)
at it.treis.utils.freemarker.CategoryCachedQueryResultDirective.execute(CategoryCachedQueryResultDirective.java:202)
at freemarker.core.Environment.visit(Environment.java:445)
at freemarker.core.UnifiedCall.accept(UnifiedCall.java:101)
at freemarker.core.Environment.visit(Environment.java:366)
at freemarker.core.Environment.invoke(Environment.java:775)
at freemarker.core.UnifiedCall.accept(UnifiedCall.java:83)
at freemarker.core.Environment.visit(Environment.java:366)
at freemarker.core.Environment.visitAndTransform(Environment.java:495)
at freemarker.core.CompressedBlock.accept(CompressedBlock.java:42)
at freemarker.core.Environment.visit(Environment.java:366)
at freemarker.core.Environment$NestedElementTemplateDirectiveBody.render(Environment.java:2900)
at it.treis.utils.freemarker.CacheDirective.execute(CacheDirective.java:102)
at freemarker.core.Environment.visit(Environment.java:445)
at freemarker.core.UnifiedCall.accept(UnifiedCall.java:101)
at freemarker.core.Environment.visit(Environment.java:366)
at freemarker.core.Environment.invoke(Environment.java:775)
at freemarker.core.UnifiedCall.accept(UnifiedCall.java:83)
at freemarker.core.Environment.visit(Environment.java:330)
at freemarker.core.Environment.visit(Environment.java:336)
at freemarker.core.Environment.process(Environment.java:309)
at freemarker.template.Template.process(Template.java:384)
at org.apache.struts2.views.freemarker.FreemarkerResult.doExecute(FreemarkerResult.java:223)
at org.apache.struts2.dispatcher.StrutsResultSupport.execute(StrutsResultSupport.java:193)
at com.opensymphony.xwork2.DefaultActionInvocation.executeResult(DefaultActionInvocation.java:372)
at com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:276)
at it.treis.smartmedia.navigation.interceptors.PrepareParametersInterceptor.intercept(PrepareParametersInterceptor.java:183)
at com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:245)
at it.treis.smartmedia.navigation.interceptors.SubscriptionTokenMatcherInterceptor.intercept(SubscriptionTokenMatcherInterceptor.java:46)
at com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:245)
at org.apache.struts2.interceptor.DeprecationInterceptor.intercept(DeprecationInterceptor.java:41)
at com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:245)
at org.apache.struts2.interceptor.debugging.DebuggingInterceptor.intercept(DebuggingInterceptor.java:256)
at com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:245)
at com.opensymphony.xwork2.interceptor.DefaultWorkflowInterceptor.doIntercept(DefaultWorkflowInterceptor.java:168)
at com.opensymphony.xwork2.interceptor.MethodFilterInterceptor.intercept(MethodFilterInterceptor.java:98)
at com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:245)
at com.opensymphony.xwork2.validator.ValidationInterceptor.doIntercept(ValidationInterceptor.java:265)
at org.apache.struts2.interceptor.validation.AnnotationValidationInterceptor.doIntercept(AnnotationValidationInterceptor.java:76)
at com.opensymphony.xwork2.interceptor.MethodFilterInterceptor.intercept(MethodFilterInterceptor.java:98)
at com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:245)
at com.opensymphony.xwork2.interceptor.ConversionErrorInterceptor.intercept(ConversionErrorInterceptor.java:138)
at com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:245)
at com.opensymphony.xwork2.interceptor.ParametersInterceptor.doIntercept(ParametersInterceptor.java:229)
at com.opensymphony.xwork2.interceptor.MethodFilterInterceptor.intercept(MethodFilterInterceptor.java:98)
at com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:245)
at com.opensymphony.xwork2.interceptor.ParametersInterceptor.doIntercept(ParametersInterceptor.java:229)
at com.opensymphony.xwork2.interceptor.MethodFilterInterceptor.intercept(MethodFilterInterceptor.java:98)
at com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:245)
at com.opensymphony.xwork2.interceptor.StaticParametersInterceptor.intercept(StaticParametersInterceptor.java:191)
at com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:245)
at org.apache.struts2.interceptor.MultiselectInterceptor.intercept(MultiselectInterceptor.java:73)
at com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:245)
at org.apache.struts2.interceptor.DateTextFieldInterceptor.intercept(DateTextFieldInterceptor.java:125)
at com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:245)
at org.apache.struts2.interceptor.CheckboxInterceptor.intercept(CheckboxInterceptor.java:91)
at com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:245)
at org.apache.struts2.interceptor.FileUploadInterceptor.intercept(FileUploadInterceptor.java:253)
at com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:245)
at com.opensymphony.xwork2.interceptor.ModelDrivenInterceptor.intercept(ModelDrivenInterceptor.java:100)
at com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:245)
at com.opensymphony.xwork2.interceptor.ScopedModelDrivenInterceptor.intercept(ScopedModelDrivenInterceptor.java:141)
at com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:245)
at com.opensymphony.xwork2.interceptor.ChainingInterceptor.intercept(ChainingInterceptor.java:145)
at com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:245)
at com.opensymphony.xwork2.interceptor.PrepareInterceptor.doIntercept(PrepareInterceptor.java:171)
at com.opensymphony.xwork2.interceptor.MethodFilterInterceptor.intercept(MethodFilterInterceptor.java:98)
at com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:245)
at com.opensymphony.xwork2.interceptor.I18nInterceptor.intercept(I18nInterceptor.java:140)
at com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:245)
at org.apache.struts2.interceptor.ServletConfigInterceptor.intercept(ServletConfigInterceptor.java:164)
at com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:245)
at com.opensymphony.xwork2.interceptor.AliasInterceptor.intercept(AliasInterceptor.java:193)
at com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:245)
at com.opensymphony.xwork2.interceptor.ExceptionMappingInterceptor.intercept(ExceptionMappingInterceptor.java:189)
at com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:245)
at org.apache.struts2.impl.StrutsActionProxy.execute(StrutsActionProxy.java:54)
at org.apache.struts2.dispatcher.Dispatcher.serviceAction(Dispatcher.java:575)
at org.apache.struts2.dispatcher.ng.ExecuteOperations.executeAction(ExecuteOperations.java:81)
at org.apache.struts2.dispatcher.ng.filter.StrutsPrepareAndExecuteFilter.doFilter(StrutsPrepareAndExecuteFilter.java:99)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:166)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:142)
at com.thetransactioncompany.cors.CORSFilter.doFilter(CORSFilter.java:209)
at com.thetransactioncompany.cors.CORSFilter.doFilter(CORSFilter.java:244)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:166)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:142)
at org.apache.catalina.core.StandardWrapperValve.invoke(StandardWrapperValve.java:166)
at org.apache.catalina.core.StandardContextValve.invoke(StandardContextValve.java:88)
at org.apache.catalina.authenticator.AuthenticatorBase.invoke(AuthenticatorBase.java:481)
at org.apache.catalina.core.StandardHostValve.invoke(StandardHostValve.java:127)
at org.apache.catalina.valves.ErrorReportValve.invoke(ErrorReportValve.java:83)
at org.apache.catalina.valves.AbstractAccessLogValve.invoke(AbstractAccessLogValve.java:643)
at org.apache.catalina.core.StandardEngineValve.invoke(StandardEngineValve.java:72)
at org.apache.catalina.valves.RemoteIpValve.invoke(RemoteIpValve.java:763)
at org.apache.catalina.connector.CoyoteAdapter.service(CoyoteAdapter.java:344)
at org.apache.coyote.http11.Http11Processor.service(Http11Processor.java:398)
at org.apache.coyote.AbstractProcessorLight.process(AbstractProcessorLight.java:63)
at org.apache.coyote.AbstractProtocol$ConnectionHandler.process(AbstractProtocol.java:935)
at org.apache.tomcat.util.net.NioEndpoint$SocketProcessor.doRun(NioEndpoint.java:1831)
at org.apache.tomcat.util.net.SocketProcessorBase.run(SocketProcessorBase.java:52)
at org.apache.tomcat.util.threads.ThreadPoolExecutor.runWorker(ThreadPoolExecutor.java:973)
at org.apache.tomcat.util.threads.ThreadPoolExecutor$Worker.run(ThreadPoolExecutor.java:491)
at org.apache.tomcat.util.threads.TaskThread$WrappingRunnable.run(TaskThread.java:63)
at java.base/java.lang.Thread.run(Thread.java:829)